Author

S. Kutluay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kumar· 2 shared J. E. Eschbach· 2 shared K. Davis· 2 shared A. L. Hansen· 1 shared A. N. Engelman· 1 shared B. S. Tolbert· 1 shared C. Shema Mugisha· 1 shared D. Potoyan· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. Kumar

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3 papers

Recent·Most cited

Thermodynamic Coupling of the tandem RRM domains of hnRNP A1 underlie its Pleiotropic RNA Binding Functions

J. D. Levengood, D. Potoyan, S. Penumutchu, A. Kumar, Y. Wang, A. L. Hansen, S. Kutluay, J. Roche, B. S. Tolbert

This study shows that thermodynamic coupling between tandem RRM domains of hnRNP A1 is essential for its allosteric RNA binding functions and stability under pressure.

bioRxiv · Aug 17, 2023 · PreprintBiochemistry

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

C. Shema Mugisha, T. Dinh, A. Kumar, K. Tenneti, J. E. Eschbach, K. Davis, R. Gifford, M. Kvaratskhelia, S. Kutluay

This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.

bioRxiv · Dec 16, 2021Microbiology

Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

J. E. Eschbach, J. L. Elliott, W. Li, K. K. Zadrozny, K. Davis, S. Mohammed, D. Q. Lawson, O. Pornillos, A. N. Engelman, S. Kutluay

This study shows that destabilizing the HIV-1 capsid lattice leads to premature loss of the viral genome and integrase enzyme in infected cells.

bioRxiv · Mar 26, 2020Microbiology