Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA
C. Shema Mugisha, T. Dinh, A. Kumar, K. Tenneti, J. E. Eschbach, K. Davis, R. Gifford, M. Kvaratskhelia, S. Kutluay
This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.
bioRxiv · Dec 16, 2021Microbiology