Author

T. Dinh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. Kvaratskhelia· 3 shared A. Biswas· 1 shared A. G. Zimmer-Faust· 1 shared A. Kumar· 1 shared A. N. Engelman· 1 shared A. Rajaraman· 1 shared A. S. Annamalai· 1 shared A. Saghir· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersMicrobiology

M. Kvaratskhelia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

T. Dinh, Z. Tber, J. S. Rey, S. Mengshetti, A. S. Annamalai, R. Haney, L. Briganti, F. Amblard, J. R. Fuchs, P. Cherepanov, K. Kim, R. F. Schinazi, J. R. Perilla, B. Kim, M. Kvaratskhelia

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.

bioRxiv · Jan 26, 2024Microbiology

Longitudinal metatranscriptomic sequencing of Southern California wastewater representing 16 million people from August 2020-21 reveals widespread transcription of antibiotic resistance genes.

J. A. Rothman, A. Saghir, S.-A. Chung, N. Boyajian, T. Dinh, J. Kim, J. Oval, V. Sharavanan, C. York, A. G. Zimmer-Faust, K. Langlois, J. A. Steele, J. F. Griffith, K. L. Whiteson

This study uses longitudinal metatranscriptomic sequencing of wastewater to track antibiotic resistance genes and microbial activity across 16 million people in Southern California.

bioRxiv · Aug 2, 2022Microbiology

An NKX-COUP-TFII genomic code for mucosal vascular addressins and organ morphogenesis

t. t. Dinh, M. Xiang, A. Rajaraman, Y. Wang, N. Salazar, W. Roper, S. Rhee, K. Brulois, E. O'Hara, H. Keifel, T. Dinh, D. Gonzalez, E. Bao, K. Red-Horse, P. Balogh, , E. Butcher

The paper identifies a genomic code involving NKX-COUP-TFII elements that regulate mucosal vascular addressin expression and organ morphogenesis.

bioRxiv · Feb 17, 2022 · PreprintImmunology

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

C. Shema Mugisha, T. Dinh, A. Kumar, K. Tenneti, J. E. Eschbach, K. Davis, R. Gifford, M. Kvaratskhelia, S. Kutluay

This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.

bioRxiv · Dec 16, 2021Microbiology