Author

M. Kvaratskhelia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

T. Dinh· 3 shared A. N. Engelman· 2 shared J. E. Eschbach· 2 shared M. Li· 2 shared P. C. Koneru· 2 shared R. Craigie· 2 shared A. Biswas· 1 shared A. Kumar· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

T. Dinh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

T. Dinh, Z. Tber, J. S. Rey, S. Mengshetti, A. S. Annamalai, R. Haney, L. Briganti, F. Amblard, J. R. Fuchs, P. Cherepanov, K. Kim, R. F. Schinazi, J. R. Perilla, B. Kim, M. Kvaratskhelia

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.

bioRxiv · Jan 26, 2024Microbiology

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions

B. Layish, R. Goli, H. Flick, S.-W. Huang, R. Zhang, M. Kvaratskhelia, M. Kane

This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.

bioRxiv · Nov 16, 2023Microbiology

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

N. E. Sapp, N. Burge, K. Cox, S. Thapa, P. Prakash, M. Balasubramaniam, D. Christensen, M. Li, J. Linderberger, M. Kvaratskhelia, W. I. Sundquist, J. Pandhare, R. Craigie, M. G. Poirier, C. Dash

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

bioRxiv · Feb 16, 2022 · PreprintBiochemistry

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

C. Shema Mugisha, T. Dinh, A. Kumar, K. Tenneti, J. E. Eschbach, K. Davis, R. Gifford, M. Kvaratskhelia, S. Kutluay

This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.

bioRxiv · Dec 16, 2021Microbiology

Exploring the Free Energy Landscape and Thermodynamics of Protein-Protein AssociationAssociation: HIV-1 Integrase Multimerization Induced by an Allosteric Inhibitor

N. Deng, C. Tse, L. Wickstrom, M. Kvaratskhelia, E. Gallicchio, R. Levy

This paper investigates the thermodynamics and free energy landscape of HIV-1 integrase multimerization induced by an allosteric inhibitor, revealing short-range interactions and enthalpy-driven binding.

bioRxiv · Jun 29, 2020Biophysics

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

J. Elliott, J. E. Eschbach, P. C. Koneru, W. Li, M. Puray Chavez, D. Townsend, D. Lawson, A. N. Engelman, M. Kvaratskhelia, S. B. Kutluay

This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.

bioRxiv · Dec 18, 2019Microbiology

N6-methyladenosine Binding Proteins Negatively Regulate HIV-1 Infectivity and Viral Production

W. Lu, N. Tirumuru, P. C. Koneru, C. Liu, M. Kvaratskhelia, C. He, L. Wu

This study shows YTHDF1-3 proteins inhibit HIV-1 infection by binding m6A-modified viral RNA, reducing reverse transcription and viral production.

bioRxiv · Mar 1, 2018Microbiology