S. L. Bullock

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

This study identifies HEATR5B as a novel dynein-dynactin interactor that promotes AP1-bound endosomal membrane motility and Golgi transport in human and Drosophila cells.

Genome-scale requirements for dynein-based trafficking revealed by a high-content arrayed CRISPR screen

The paper uses a CRISPR screen to identify genes critical for dynein-based trafficking, revealing novel regulators and functional relationships in microtubule transport.

Tropomyosin 1-I/C co-ordinates kinesin-1 and dynein motors during oskar mRNA transport

This study shows Tm1-I/C coordinates kinesin-1 and dynein during oskar mRNA transport by inhibiting kinesin-1 until it is needed in the oocyte.

An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport

The paper shows that Staufen and Egl interact to switch motor proteins during oskar mRNA transport in Drosophila oocytes, enabling proper localization.

Lis1 activates dynein motility by pairing it with dynactin

This study shows Lis1 activates dynein motility by releasing it from auto-inhibition and promoting complex formation with dynactin, enhancing transport efficiency.

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

The paper reconstitutes microtubule minus end-directed mRNA transport using purified components and shows RNA is required for dynein activation.

DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes

This study investigates how DYNC1H1 mutations affect dynein motility and links these defects to neurological diseases.