S. Ma

This study shows Riluzole reduces growth and improves response to endocrine therapy in ER+ breast cancer models.

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

This study develops an AI system to identify fetal nucleated red blood cells using deep learning, achieving high accuracy and sensitivity in testing.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

The paper describes a Cretaceous insect with exaggerated leaf-like antennae, suggesting sensory organs played a significant role in sexual selection and evolutionary trade-offs.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

The paper uses spatial transcriptomics to model metabolic gene expression in prostate cancer, identifying spatially distinct metabolic vulnerabilities and potential drug targets.

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.

This study improves the specificity of adenine base editor ABE7.10 by replacing SpCas9 with high-fidelity Cas9 variants, showing reduced off-target activity in four test sites.

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

The paper investigates the spatial organization of S-layer biogenesis in Clostridium difficile, finding that SlpA secretion is delocalized while S-layer formation occurs at sites of cell wall synthesis.

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.