Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD
J. F. Abenza, L. Rossetti, M. Mouelhi, J. Burgues, I. Andreu, K. Kennedy, P. Roca-Cusachs, S. Marco, J. Garcia-Ojalvo, X. Trepat
The paper shows mechanical cues regulate the circadian clock in fibroblasts via YAP/TAZ and TEAD, disrupting Rev-erb oscillations when YAP/TAZ translocate to the nucleus.
bioRxiv · Feb 4, 2022Cell Biology