Author

A. Chandrashekar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Bioengineering· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:non-human primate· 5 Research Focus:drug response / drug discovery· 4 Organism:rat· 4 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. H. Barouch· 8 shared J. Yu· 7 shared K. McMahan· 6 shared A. Cook· 5 shared E. Teow· 5 shared H. Andersen· 5 shared L. Pessaint· 5 shared J. Liu· 4 shared

Activity by Year

2020-2022 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersImmunology

D. H. Barouch

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11 papers

Recent·Most cited

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

A. Chandrashekar, J. Yu, K. McMahan, C. Jacob-Dolan, J. Liu, X. He, D. Hope, T. Anioke, J. Barrett, B. Chung, N. Hachmann, M. Lifton, J. Miller, O. Powers, M. Sciacca, , D. H. Barouch

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

bioRxiv · Feb 6, 2022Microbiology

A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine

K. Chakraborty, A. Chandrashekar, A. Sidaway, E. Latta, J. Yu, K. McMahan, C. Manickam, K. Kroll, M. Mosher, R. K. Reeves, R. Gam, E. Arthofer, M. Choudhry, D. H. Barouch, T. Henley

This paper describes a CRISPR-engineered cellular vaccine designed to mimic natural immunity, showing robust neutralizing antibody responses and reduced viral load in non-human primates.

bioRxiv · Dec 28, 2021 · PreprintImmunology

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques

R. R. Cobb, J. Nkolola, P. Gilchuk, A. Chandrashekar, R. V. House, C. G. Earnhart, N. M. Dorsey, S. A. Hopkins, D. M. Snow, R. E. Chen, L. A. VanBlargan, M. Hechenblaickner, B. Hoppe, L. Collins, M. T. Tomic, , J. E. Crowe

This study shows that a combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques and neutralizes variants of concern in vitro.

bioRxiv · Sep 27, 2021 · PreprintImmunology

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

J. Yu, N. Collins, N. B. Mercado, K. McMahan, A. Chandrashekar, J. Liu, T. Anioke, A. Chang, V. Giffin, D. Hope, D. Sellers, F. Nampanya, S. Gardner, J. Barrett, H. Wan, , D. H. Barouch

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

bioRxiv · Sep 13, 2021Microbiology

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

M. Gebre, S. Rauch, N. Roth, J. Yu, A. Chandrashekar, N. Mercado, X. He, J. Liu, K. McMahan, A. Martinot, T. Giffin, D. Hope, S. Patel, D. Sellers, O. Sanborn, , D. H. Barouch

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

bioRxiv · Aug 13, 2021 · PreprintImmunology

PROTECTIVE ROLE FOR SMOOTH MUSCLE CELL HEPCIDIN IN ABDOMINAL AORTIC ANEURYSM

P. Loick, G. Mohammad, I. Cassinmjee, A. Chandrashekar, P. Lapolla, A. Carrington, A. Handa, R. Lee, S. Lakhal-Littleton

This study shows that HAMP produced by smooth muscle cells protects against abdominal aortic aneurysm by suppressing LCN2.

bioRxiv · Jul 30, 2021Physiology

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

N. C. Dalvie, L. H. Tostanoski, S. A. Rodriguez-Aponte, K. Kaur, S. Bajoria, O. Kumru, A. J. Martinot, A. Chandrashekar, K. McMahan, N. B. Mercado, J. Yu, A. Chang, V. M. Giffin, F. Nampanya, S. Patel, , D. H. Barouch

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

bioRxiv · Jul 13, 2021 · PreprintImmunology

SARS-CoV-2 binding and neutralizing antibody levels after vaccination with Ad26.COV2.S predict durable protection in rhesus macaques

R. Roozendaal, L. Solforosi, D. Stieh, J. Serroyen, R. Straetemans, F. Wegmann, S. K. Rosendahl Huber, J. E. M. van der Lubbe, J. Hendriks, M. le Gars, L. Dekking, D. N. Czapska-Casey, N. Guimera, S. Janssen, S. Tete, , R. Zahn

This study shows that Ad26.COV2.S vaccine provides long-lasting protection in rhesus macaques, predicted by binding and neutralizing antibody levels against SARS-CoV-2.

bioRxiv · Jan 30, 2021Immunology

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

X. He, A. Chandrashekar, R. C. Zahn, F. Wegmann, J. Yu, N. B. Mercado, K. McMahan, A. J. Martinot, C. Piedra-Mora, S. Beecy, S. Ducat, R. Chamanza, S. Rosendahl Huber, L. van der Fits, E. N. Borducchi, , D. H. Barouch

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

bioRxiv · Jan 27, 2021Immunology

Development of a Novel Index to Characterise Arterial Dynamics Using Ultrasound Imaging

J. Ward, X. Cheng, Y. Xiao, P. Lapolla, A. Chandrashekar, A. Handa, R. Cleveland, R. Lee

The paper develops a brachial artery relaxation index (BARI) to predict abdominal aortic aneurysm (AAA) growth but finds no significant correlation between BARI and future AAA growth.

bioRxiv · Oct 31, 2020Bioengineering

Higher Order AMMI (HO-AMMI) analysis: A novel stability model to study genotype-location interactions

A. Chandrashekar, A. R. Fiyaz, B. SK, N. Kumar, G. K, p. Kona, K. Rani, R. T

This paper introduces HO-AMMI, a stability model to analyze genotype-location interactions, showing it better separates GLI from GYI and improves genotype ranking for target locations.

bioRxiv · Oct 5, 2020Plant Biology