Author

K. McMahan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Research Focus:drug response / drug discovery· 4 Organism:non-human primate· 4 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Organism:rat· 2

Frequent Co-Authors

D. H. Barouch· 8 shared J. Yu· 7 shared A. Chandrashekar· 6 shared H. Andersen· 6 shared J. Liu· 6 shared A. Cook· 5 shared E. Teow· 5 shared L. Pessaint· 5 shared

Activity by Year

2021-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersMicrobiology

D. H. Barouch

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Persistent Activation of Chronic Inflammatory Pathways in Long Covid

M. Aid, K. McMahan, N. Hachmann, J. Miller, E. Borducchi, D. Hope, M. Rowe, E. Schonberg, S. Thai, A.-r. Collier, J. Mullington, D. Barouch

The paper identifies persistent activation of inflammatory pathways in Long Covid patients compared to controls and links acute infection severity to Long Covid development.

bioRxiv · May 11, 2024 · PreprintImmunology

Genetic characterization of the zoonotic parasite Ancylostoma caninum in the central and eastern USA

T. A. Quintana, W. L. Johnson, D. Ritchie, V. Smith, K. A. Martin, K. McMahan, M. T. Brewer, J. R. J. Jesudoss Chelladurai

This study characterizes Ancylostoma caninum genetic diversity in the central and eastern USA using cox1 sequences, identifying 25 haplotypes and showing moderate geographical structuring.

bioRxiv · Dec 22, 2022 · PreprintMicrobiology

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

A.-r. Collier, J. Miller, N. Hachmann, K. McMahan, J. Liu, E. Bondzie, L. Gallup, M. Rowe, E. Shonberg, S. Thai, J. Barrett, E. Borducchi, E. Bouffard, C. Jacob-Dolan, C. Mazurek, , D. Barouch

This study compares neutralizing antibody titers after monovalent and bivalent mRNA boosters against SARS-CoV-2, finding comparable levels against BA.5.

bioRxiv · Oct 24, 2022Immunology

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

A. Chandrashekar, J. Yu, K. McMahan, C. Jacob-Dolan, J. Liu, X. He, D. Hope, T. Anioke, J. Barrett, B. Chung, N. Hachmann, M. Lifton, J. Miller, O. Powers, M. Sciacca, , D. H. Barouch

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

bioRxiv · Feb 6, 2022Microbiology

Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters

K. McMahan, V. Giffin, L. Tostanoski, B. Chung, M. Siamatu, M. Suthar, P. Halfmann, Y. Kawaoka, C. Piedra-Mora, A. Martinot, S. Kar, H. Andersen, M. G. Lewis, D. H. Barouch

This study shows the SARS-CoV-2 Omicron variant causes less weight loss in hamsters than previous variants, suggesting reduced lower respiratory tract disease severity.

bioRxiv · Jan 2, 2022Microbiology

A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine

K. Chakraborty, A. Chandrashekar, A. Sidaway, E. Latta, J. Yu, K. McMahan, C. Manickam, K. Kroll, M. Mosher, R. K. Reeves, R. Gam, E. Arthofer, M. Choudhry, D. H. Barouch, T. Henley

This paper describes a CRISPR-engineered cellular vaccine designed to mimic natural immunity, showing robust neutralizing antibody responses and reduced viral load in non-human primates.

bioRxiv · Dec 28, 2021 · PreprintImmunology

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

J. Yu, N. Collins, N. B. Mercado, K. McMahan, A. Chandrashekar, J. Liu, T. Anioke, A. Chang, V. Giffin, D. Hope, D. Sellers, F. Nampanya, S. Gardner, J. Barrett, H. Wan, , D. H. Barouch

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

bioRxiv · Sep 13, 2021Microbiology

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

M. Gebre, S. Rauch, N. Roth, J. Yu, A. Chandrashekar, N. Mercado, X. He, J. Liu, K. McMahan, A. Martinot, T. Giffin, D. Hope, S. Patel, D. Sellers, O. Sanborn, , D. H. Barouch

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

bioRxiv · Aug 13, 2021 · PreprintImmunology

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

N. C. Dalvie, L. H. Tostanoski, S. A. Rodriguez-Aponte, K. Kaur, S. Bajoria, O. Kumru, A. J. Martinot, A. Chandrashekar, K. McMahan, N. B. Mercado, J. Yu, A. Chang, V. M. Giffin, F. Nampanya, S. Patel, , D. H. Barouch

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

bioRxiv · Jul 13, 2021 · PreprintImmunology

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

L. Tostanoski, L. Gralinski, D. Martinez, A. Schaefer, S. Mahrokhian, Z. Li, F. Nampanya, H. Wan, J. Yu, A. Chang, J. Liu, K. McMahan, K. Dinnon, S. R. Leist, R. S. Baric, D. H. Barouch

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

bioRxiv · Jun 14, 2021Microbiology

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

X. He, A. Chandrashekar, R. C. Zahn, F. Wegmann, J. Yu, N. B. Mercado, K. McMahan, A. J. Martinot, C. Piedra-Mora, S. Beecy, S. Ducat, R. Chamanza, S. Rosendahl Huber, L. van der Fits, E. N. Borducchi, , D. H. Barouch

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

bioRxiv · Jan 27, 2021Immunology