Author

S. S. Najera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. L. Meier· 2 shared M. Perez· 2 shared A. N. Conte· 1 shared C. A. Briney· 1 shared D. W. Bak· 1 shared E. Weerapana· 1 shared K. D. Nance· 1 shared M. Linehan· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

J. L. Meier

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2 papers

Recent·Most cited

Conditional covalent lethality driven by oncometabolite accumulation

M. Perez, K. D. Nance, D. W. Bak, S. T. Gamage, S. S. Najera, A. N. Conte, W. M. Linehan, E. Weerapana, J. L. Meier

The paper identifies a covalent small molecule, MP-1, that exhibits FH-dependent cytotoxicity in HLRCC by targeting cysteine residues, including in TRMT1, and shows TRMT1 overexpression can rescue tRNA methylation inhibition.

bioRxiv · Apr 26, 2022Biochemistry

An Oncometabolite Isomer Rapidly Induces A Pathophysiological Protein Modification

S. E. Bergholtz, C. A. Briney, S. S. Najera, M. Perez, M. Linehan, J. L. Meier

This study develops chemical agonists to induce S-succination, a posttranslational modification linked to oncometabolites, and demonstrates their cellular effects.

bioRxiv · Jan 11, 2020Biochemistry