Author

S. T. Gamage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

J. L. Meier· 4 shared T. Andresson· 2 shared A. D. Tran· 1 shared A. Lopes· 1 shared A. N. Conte· 1 shared B. Yin· 1 shared C. N. Evans· 1 shared C. N. Link· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

J. L. Meier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular Basis for RNA Cytidine Acetylation by NAT10

M. Zhou, S. T. Gamage, K. Tran, D. Bartee, X. Wei, B. Yin, S. Berger, J. L. Meier, R. Marmorstein

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

bioRxiv · Mar 27, 2024 · PreprintBiophysics

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

R. Amin, N.-H. Ha, T. Qiu, R. Holewinski, K. C. Lam, A. Lopes, H. Liu, A. D. Tran, M. P. Lee, S. T. Gamage, T. Andresson, R. S. Goldszmid, J. L. Meier, K. Hunter

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

bioRxiv · Jan 24, 2024 · PreprintCancer Biology

Conditional covalent lethality driven by oncometabolite accumulation

M. Perez, K. D. Nance, D. W. Bak, S. T. Gamage, S. S. Najera, A. N. Conte, W. M. Linehan, E. Weerapana, J. L. Meier

The paper identifies a covalent small molecule, MP-1, that exhibits FH-dependent cytotoxicity in HLRCC by targeting cysteine residues, including in TRMT1, and shows TRMT1 overexpression can rescue tRNA methylation inhibition.

bioRxiv · Apr 26, 2022Biochemistry

Protonation-Dependent Sequencing of 5-Formylcytidine in RNA

C. N. Link, S. T. Gamage, D. A. Gallimore, R. Kopajtich, C. N. Evans, S. R. Nance, S. D. Fox, T. Andresson, R. Chari, J. Ivanic, H. Prokisch, J. L. Meier

This paper develops a protonation-dependent sequencing method to detect 5-formylcytidine and 5-carboxycytidine in RNA, demonstrating its application in human tRNA and a 5fC-deficiency model.

bioRxiv · Nov 23, 2021Biochemistry