Author

K. D. Nance

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. L. Meier· 3 shared A. L. Thorpe· 1 shared A. N. Conte· 1 shared D. Bartee· 1 shared D. C. Montgomery· 1 shared D. W. Bak· 1 shared E. Weerapana· 1 shared J. Montano· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

J. L. Meier

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Author profile →

3 papers

Recent·Most cited

Conditional covalent lethality driven by oncometabolite accumulation

M. Perez, K. D. Nance, D. W. Bak, S. T. Gamage, S. S. Najera, A. N. Conte, W. M. Linehan, E. Weerapana, J. L. Meier

The paper identifies a covalent small molecule, MP-1, that exhibits FH-dependent cytotoxicity in HLRCC by targeting cysteine residues, including in TRMT1, and shows TRMT1 overexpression can rescue tRNA methylation inhibition.

bioRxiv · Apr 26, 2022Biochemistry

Site-Specific Synthesis of N4-Acetylcytidine in RNA Reveals Physiological Duplex Stabilization

D. Bartee, K. D. Nance, J. L. Meier

This study synthesizes and characterizes N4-acetylcytidine (ac4C) in RNA to assess its impact on duplex stability and mismatch discrimination in eukaryotic sequences.

bioRxiv · Nov 12, 2021Biochemistry

A systems chemoproteomic analysis of acyl-CoA/protein interactions

M. J. Levy, D. C. Montgomery, M. E. Sardiu, S. E. Bergholtz, K. D. Nance, J. Montano, A. L. Thorpe, S. D. Fox, Q. Lin, T. Andresson, L. Florens, M. P. Washburn, J. L. Meier

The paper develops a chemoproteomic platform to analyze acyl-CoA/protein interactions and identifies biological processes affected by acetyl-CoA levels.

bioRxiv · Jul 18, 2019Biochemistry