Author

D. W. Bak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

E. Weerapana· 5 shared J. L. Meier· 3 shared W. M. Linehan· 3 shared M. Perez· 2 shared S. E. Bergholtz· 2 shared A. Alpsoy· 1 shared A. Bavari· 1 shared A. L. Thorpe· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersBiochemistry

E. Weerapana

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Author profile →

5 papers

Recent·Most cited

Conditional covalent lethality driven by oncometabolite accumulation

M. Perez, K. D. Nance, D. W. Bak, S. T. Gamage, S. S. Najera, A. N. Conte, W. M. Linehan, E. Weerapana, J. L. Meier

The paper identifies a covalent small molecule, MP-1, that exhibits FH-dependent cytotoxicity in HLRCC by targeting cysteine residues, including in TRMT1, and shows TRMT1 overexpression can rescue tRNA methylation inhibition.

bioRxiv · Apr 26, 2022Biochemistry

An infection-activated redox switch promotes tumor growth

Y. Kovalyova, D. W. Bak, E. M. Gordon, C. Fung, J. H. B. Shuman, T. L. Cover, M. R. Amieva, E. Weerapana, S. K. Hatzios

The paper shows that oxidation of legumain at Cys219 by H. pylori infection promotes tumor growth and mortality in a xenograft model.

bioRxiv · May 25, 2021 · PreprintMicrobiology

Monitoring iron-sulfur cluster occupancy across the E. coli proteome using chemoproteomics

D. W. Bak, E. Weerapana

This paper develops a chemoproteomic method to monitor Fe-S cluster occupancy in E. coli, identifying new Fe-S proteins and elucidating scaffold protein roles in Fe-S biogenesis.

bioRxiv · Apr 1, 2021 · PreprintBiochemistry

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite

M. Perez, D. W. Bak, S. E. Bergholtz, D. R. Crooks, Y. Yang, W. M. Linehan, E. Weerapana, J. L. Meier

The paper reports a chemoproteomic analysis of cysteine reactivity in HLRCC cells upon FH rescue, revealing transcriptional and posttranslational regulation of cysteine residues.

bioRxiv · Jun 25, 2020Cancer Biology

A chemoproteomic portrait of the oncometabolite fumarate

R. A. Kulkarni, D. W. Bak, D. Wei, S. E. Bergholtz, C. A. Briney, J. H. Shrimp, A. L. Thorpe, A. Bavari, A. Alpsoy, M. Levy, L. Florens, M. P. Washburn, E. C. Dykhuizen, N. Frizzell, E. Weerapana, , J. L. Meier

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

bioRxiv · Mar 22, 2018Cancer Biology