J. Mason

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe

This study shows FBH1 deficiency increases mitotic catastrophe in response to WEE1 inhibition, despite reduced replication stress signaling.

Filopodial protrusion driven by density-dependent Ena-TOCA-1 interactions

The paper shows TOCA-1 interacts with Ena/VASP proteins via SH3 domains to drive filopodial protrusion in Xenopus axons.

Sex differences in allometry for mouse phenotypic traits indicate that females are not scaled males

The paper quantifies sex differences in allometric relationships for 375 phenotypic traits in mice, finding that body weight differences do not fully explain sex differences in trait values.

A thermodynamic model for interpreting tryptophan excitation-energy-dependent fluorescence spectra provides insight into protein conformational sampling and stability

The paper develops a thermodynamic model to quantify the relationship between the tryptophan red edge excitation shift effect and protein flexibility, using examples across multiple scales and protein types.

Piperacillin/tazobactam resistant, cephalosporin susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types

The paper identifies genetic diversity and resistance mechanisms in E. coli with piperacillin/tazobactam resistance but third-generation cephalosporin susceptibility.

Sex and Power: sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

The paper tests sex differences in trait variability using mouse data, finding trait-dependent patterns that challenge existing hypotheses and highlight eco-evolutionary and statistical implications.

Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

A direct role for SNX9 in the biogenesis of filopodia

The paper identifies SNX9 as an endogenous component of filopodia and shows its role in filopodia biogenesis through antibody-based screening.

Constrained actin dynamics emerges from variable compositions of actin regulatory protein complexes

The paper shows that heterogeneous actin regulatory complexes can produce stable filopodia-like structures through stochastic dynamics.

Sclerostin Deficiency Alters Peripheral B Lymphocyte Responses in Mice

This study shows that sclerostin deficiency in mice leads to age-dependent changes in B cell development and immune responses, affecting both T-independent and T-dependent antigen responses.

PDX Finder: A Portal for Patient-Derived tumor Xenograft Model Discovery

PDX Finder is a global catalog of PDX models that harmonizes metadata to improve discoverability across diverse repositories.

Filopodyan: An Open-Source Pipeline For The Analysis Of Filopodia

Filopodyan quantifies fluorescence and dynamics of filopodia in multiple cell types, revealing molecular heterogeneity in ENA/VASP recruitment during filopodia formation.