Pragya Goel

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntingtons disease

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

This study uses botulinum neurotoxin to isolate neurotransmission from tonic and phasic neurons in Drosophila, revealing heterosynaptic plasticity rules.

Excess glutamate release triggers subunit-specific homeostatic receptor scaling

This study shows that excess glutamate release selectively regulates GluR subtypes through competition and Ca2+ signaling in Drosophila.

Distinct target-specific mechanisms homeostatically stabilize transmission at pre-and post-synaptic compartments

The paper identifies distinct target-specific mechanisms that stabilize synaptic strength at pre- and post-synaptic compartments in Drosophila neuromuscular junctions.

Presynaptic depression maintains stable synaptic strength in developmentally arrested Drosophila larvae

The paper investigates how synaptic strength is maintained in Drosophila larvae arrested in development, finding that presynaptic homeostatic depression compensates for excessive synaptic growth.

The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling

This study identifies the sleep gene insomniac as essential for retrograde homeostatic signaling by ubiquitinating targets at postsynaptic densities in Drosophila.

A screen for genes that regulate synaptic growth reveals mechanisms that stabilize synaptic strength

The paper screens Drosophila genes affecting synaptic growth and identifies three mechanisms that stabilize synaptic strength despite growth changes.

Rapid active zone remodeling consolidates presynaptic potentiation

The paper identifies a molecular mechanism for presynaptic plasticity involving rapid remodeling of active zone modules, which sustains neurotransmitter release potentiation over time.

Endogenous tagging reveals differential regulation of Ca2+ channels at single AZs during presynaptic homeostatic potentiation and depression

The paper uses CRISPR to tag Ca2+ channels in Drosophila and shows they are differentially regulated during presynaptic homeostatic potentiation and depression.