Kaikai He

Resolving synaptic events using subsynaptically targeted GCaMP8 variants

The paper introduces GCaMP8 variants targeted to synaptic compartments and develops CaFire software to quantify Ca2+ signals, showing improved sensitivity and resolution compared to existing methods.

Distinct input-specific mechanisms enable presynaptic homeostatic plasticity

The paper investigates how two distinct motor inputs contribute to presynaptic homeostatic plasticity (PHP) in Drosophila, showing input-specific mechanisms for stabilizing neuromuscular junction activity.

Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons

The paper identifies physiological and nanoscale differences in glutamatergic synapses between tonic and phasic neurons at the Drosophila neuromuscular junction.

Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

This study uses botulinum neurotoxin to isolate neurotransmission from tonic and phasic neurons in Drosophila, revealing heterosynaptic plasticity rules.

Microglia undergo rapid phenotypic transformation in acute brain slices but remain essential for neuronal synchrony

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

The paper develops an ultrasensitive GRABATP1.0 sensor to detect extracellular ATP in real time, demonstrating its use in vitro and in vivo across multiple conditions.

Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson's disease and dopaminergic neuron dysfunction

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.

2-Arachidonoylglycerol mobilization following brief synaptic stimulation in the dorsal lateral striatum requires glutamatergic and cholinergic neurotransmission

This study investigates the mechanisms of 2-AG mobilization in the dorsal lateral striatum following synaptic stimulation, revealing the roles of glutamatergic and cholinergic neurotransmission.

A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.