Multiscale brain-wide mapping of α-synuclein-driven dopaminergic degeneration and white matter impairment in α-synucleinopathy mice
Benjamin F. Combes, Sihan Dong, Martin T. Henrich, Alicia K. Rosenau, Maria Karatsoli, Jie Lu, Sepp Kollmorgen, Marco Reisert, Xunbin Wei, Tian Zeng, Hongjiang Wei, Yi Chen, Liqin Yang, Kuangyu Shi, K. Peter R. Nilsson, , Ruiqing Ni
This paper maps α-synuclein pathology and dopaminergic degeneration in mice using multimodal imaging and microscopy, showing spread along the nigrostriatal pathway and microstructural changes.
bioRxiv · May 5, 2026 · PreprintNeuroscience