Author

Shanhai Xie

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Deepak NijhawaniD· 2 shared Min FangiD· 2 shared Vishal KhivansaraiD· 2 shared Alexander SpektoriD· 1 shared Andrew T. BockusiD· 1 shared Aniruddha SarkariD· 1 shared Arin B. AuroraiD· 1 shared Ashley Leach· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Deepak NijhawanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

Shilpa Singh, Catherine E. Gleason, Min Fang, Yasmin Nabil Laimon, Vishal Khivansara, Shanhai Xie, Yavuz T. Durmaz, Aniruddha Sarkar, Kenneth H. Ngo, Varunika Savla, Yixiang Li, Muhannad Abu‐Remaileh, Xinyue Li, Marie-Anaïs Locquet, Bishma Tuladhar, , Matthew G. Oser

This paper develops cyclin A/B macrocyclic inhibitors that induce apoptosis in cancers with high E2F activity by blocking RxL-mediated interactions, showing efficacy in SCLC models.

Journal of Thoracic Oncology · Aug 1, 2025Peer-reviewedCancer Biology

A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis

Holly H. Guo, Ye Tao, Victor Emmanuel Cruz, Min Fang, Vishal Khivansara, Shanhai Xie, Ashley Leach, Divya Reddy, Johann Peterson, Jiwoong Kim, Noelle Sevilir Williams, Arin B. Aurora, Jan Peter Erzberger, Jef K. De Brabander, Deepak Nijhawan

The paper identifies NVL as a target for cancer therapy, showing that its inhibition by MM17 and MM927 suppresses tumor growth through ribosome biogenesis disruption.

bioRxiv · Jul 31, 2025 · PreprintBiochemistry