Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice
Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Mary Plascencia, Fuying Gao, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Brinda C. Prasad, Thomas Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang
This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.
bioRxiv · Jul 9, 2024 · PreprintNeuroscience