Author

Jeffrey S. Aaronson

CHDI Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Jim Rosinski· 3 shared Fuying GaoiD· 2 shared Lalini RamanathaniD· 2 shared Mary Plascencia· 2 shared Nan WangiD· 2 shared Peter LangfelderiD· 2 shared Raymond VacaiD· 2 shared Steve HorvathiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Jim Rosinski

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3 papers

Recent·Most cited

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

Peter Langfelder, Nan Wang, Lalini Ramanathan, Young Mi Oh, Seongwon Lee, Fuying Gao, Xiaofeng Gu, Matthew Stricos, Mary Plascencia, Raymond Vaca, Jeffrey Richman, Thomas Vogt, Steve Horvath, Andrew S.J. Yoo, Jeffrey S. Aaronson, , X. William Yang

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

bioRxiv · Mar 4, 2026 · PreprintGenetics

Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice

Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Mary Plascencia, Fuying Gao, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Brinda C. Prasad, Thomas Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

bioRxiv · Jul 9, 2024 · PreprintNeuroscience

Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures

John C. Obenauer, Jian Chen, Viktoria Andreeva, Jeffrey S. Aaronson, Ramee Lee, Andrea Caricasole, Jim Rosinski

The paper analyzes RNA-seq and proteomics data from Huntington disease mouse models to identify disease-specific signatures in the striatum and liver, revealing gender effects and improved proteomics analysis methods.

bioRxiv · Feb 4, 2022 · PreprintNeuroscience