Author

Si Min Lai

Manchester Academic Health Science Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Mark A. TravisiD· 2 shared Antony D. AdamsoniD· 1 shared Catherine B. LawrenceiD· 1 shared Christopher HoyleiD· 1 shared David BroughiD· 1 shared Elana H. SuperiD· 1 shared Eric Andrew AppeliD· 1 shared Francesco CoppolaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Mark A. TravisORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α

Christopher Hoyle, Rodrigo Diaz Pino, Si Min Lai, Jack Green, Antony D. Adamson, Graham Coutts, Catherine B. Lawrence, Mark A. Travis, David Brough, Gloria López‐Castejón

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

Disease Models & Mechanisms · Mar 4, 2026Peer-reviewedImmunology

Star-polymers as potent broad-spectrum extracellular virucidal antivirals

Elana H. Super, Si Min Lai, Urszula Cytlak, Francesco Coppola, Olivia M. Saouaf, Ye Eun Song, Kerriann M. Casey, Lauren J. Batt, Shannan-Leigh Macleod, Robert H. T. Bagley, Zarah Walsh, Petr Král, Eric Andrew Appel, Mark A. Travis, Samuel T. Jones

This paper discovers a broad-spectrum, non-toxic polymer virucide effective against multiple viruses at nanomolar concentrations, showing efficacy in a murine RSV model.

bioRxiv · Jul 10, 2024 · PreprintMicrobiology