Author

Sophia Flad

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Michaela FryeiD· 2 shared Alessia RuggieriiD· 1 shared Chia Ching WuiD· 1 shared Christoph DieterichiD· 1 shared Doris LindneriD· 1 shared Fotini Nina PapavasiliouiD· 1 shared Francesca TuortoiD· 1 shared Georg StoeckliniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Michaela FryeORCID

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Author profile →

2 papers

Recent·Most cited

The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover

Chia Ching Wu, Isabel S. Naarmann‐de Vries, Jonas Hartmann, Zarina Nidoieva, Kevin Kopietz, Virginie Marchand, Zeynep Özrendeci, Doris Lindner, Sophia Schelchshorn, Sophia Flad, Michaela Frye, Fotini Nina Papavasiliou, Tanja Schirmeister, Georg Stoecklin, Johanna Schott, , Alessia Ruggieri

ViREn is a two-step method that purifies dengue virus RNA with high purity, revealing a 5-methylcytosine modification mediated by NSUN6 that affects RNA turnover.

Nucleic Acids Research · Jan 7, 2026Peer-reviewedBiochemistry

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6

Tommaso Selmi, Shobbir Hussain, Sabine Dietmann, Matthias Heiß, Kayla M. Borland, Sophia Flad, Jean-Michel Carter, Rebecca A. Dennison, Ya‐Lin Huang, Stefanie M. Kellner, Susanne Bornelöv, Michaela Frye

The paper identifies NSUN6 as a methyltransferase that specifically targets mRNA 3UTR regions with the CTCCA motif, affecting translation termination but not essential for mouse development.

Nucleic Acids Research · Nov 24, 2020Peer-reviewedMolecular Biology