Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea
Maryna V. Ivanchenko, Kevin T. A. Booth, K. Domenica Karavitaki, Larisa M. Antonellis, M. Aurel Nagy, Cole W. Peters, Spencer Price, Yaqiao Li, Anton Lytvyn, Andrew R. Ward, Eric C. Griffith, Siniša Hrvatin, Michael E. Greenberg, David P. Corey
This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.
Nature Communications · Dec 16, 2025Peer-reviewedNeuroscience