Author

Steffi Klimke

University of Basel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christoph DehioiD· 3 shared Sarah Tschudin‐SutteriD· 3 shared Amanzhol KurmasheviD· 2 shared Andreas R. HierlemanniD· 2 shared Antonia Müller· 2 shared Carlos FloresiD· 2 shared Cinzia FinoiD· 2 shared Isabel Sorg· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMicrobiology

Christoph DehioORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors

Daria D. Fleckenstein, Andreas Kaczmarczyk, Niklas Breitenbach-Netter, Gili Rosenberg, Roman Peter Jakob, Isabel Sorg, Amanzhol Kurmashev, Carlos Flores, Eva Jiménez‐Siebert, Elinor Morris, Steffi Klimke, Sarah Tschudin‐Sutter, Andreas R. Hierlemann, Timm Maier, Christoph Dehio, , Knut Drescher

The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.

bioRxiv · Feb 5, 2026 · PreprintMicrobiology

Perfusable 3D human urothelial model for real-time analysis of bacterial infection dynamics and therapeutic interventions

Amanzhol Kurmashev, Isabel Sorg, Julia Alicia Boos, Lara Grassi, Benjamin Sellner, Cinzia Fino, Mehmet Girgin, Antonia Müller, Steffi Klimke, Sarah Tschudin‐Sutter, Andreas R. Hierlemann, Christoph Dehio

This paper develops a 3D human urothelial model to study UTI dynamics and therapeutic responses in real-time.

bioRxiv · Nov 12, 2025 · PreprintBioengineering

Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic Escherichia coli in human urine

Monica Ortelli, Rūta Prakapaitė, Antonia Müller, Solange Miele, Cinzia Fino, Steffi Klimke, Sarah Tschudin‐Sutter, Urs Jenal, Carlos Flores, David Bikard, Christoph Dehio

This study uses CRISPRi to identify metabolic vulnerabilities of UPEC in urine, highlighting ALS II as a druggable target.

bioRxiv · Oct 31, 2025 · PreprintMicrobiology