Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors
Daria D. Fleckenstein, Andreas Kaczmarczyk, Niklas Breitenbach-Netter, Gili Rosenberg, Roman Peter Jakob, Isabel Sorg, Amanzhol Kurmashev, Carlos Flores, Eva Jiménez‐Siebert, Elinor Morris, Steffi Klimke, Sarah Tschudin‐Sutter, Andreas R. Hierlemann, Timm Maier, Christoph Dehio, , Knut Drescher
The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.
bioRxiv · Feb 5, 2026 · PreprintMicrobiology