Sarah Tschudin‐Sutter

Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ

This study introduces HIDEN-SEQ, a transposon-insertion sequencing method for phages, to systematically map gene essentiality and uncover previously unknown viral anti-defense factors.

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors

The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.

Perfusable 3D human urothelial model for real-time analysis of bacterial infection dynamics and therapeutic interventions

This paper develops a 3D human urothelial model to study UTI dynamics and therapeutic responses in real-time.

Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic Escherichia coli in human urine

This study uses CRISPRi to identify metabolic vulnerabilities of UPEC in urine, highlighting ALS II as a druggable target.

Phylodynamic estimation of the within-host mutation rate of extended-spectrum beta-lactamase-producing Enterobacterales

The paper estimates within-host mutation rates of ESBL-producing E. coli and K. pneumoniae using phylodynamic models on longitudinal genomic data from hospitalized patients.

The effect of sequencing and assembly on the inference of horizontal gene transfer on chromosomal and plasmid phylogenies

The paper compares sequencing and assembly methods' impact on plasmid and chromosomal phylogenies and horizontal gene transfer inference in E. coli.