Timm Maier

This study identifies PAIP1 as a cofactor for mRNA export and shows it couples nuclear to cytoplasmic mRNP remodeling and poly(A) homeostasis, affecting mRNA stability and development.

The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.

This study identifies TagF as a checkpoint protein that coordinates spike-loading in T6SS assembly by preventing premature sheath formation and interacting with Hcp and TagZ.

This study identifies xenorceptides, a new class of antibiotics that target BamA in Gram-negative bacteria, showing potent activity and limited resistance.

The paper reports the high-resolution cryo-EM structure of urease from Yersinia enterocolitica, revealing the bimetal active site and enabling drug development insights.

The paper reports the crystal structure of GSDMD's C-terminal domain to analyze activation determinants and interactions with the N-terminal domain.