Author

Roman Peter Jakob

University of BaselORCID 0000-0002-6451-8656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Timm MaieriD· 3 shared Amanzhol KurmasheviD· 1 shared Amir Ata SaeiiD· 1 shared Andreas KaczmarczykiD· 1 shared Andreas R. HierlemanniD· 1 shared Andrew Yeo Jung Yeat· 1 shared Brandon I. MorinakaiD· 1 shared Carlos FloresiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

Timm MaierORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors

Daria D. Fleckenstein, Andreas Kaczmarczyk, Niklas Breitenbach-Netter, Gili Rosenberg, Roman Peter Jakob, Isabel Sorg, Amanzhol Kurmashev, Carlos Flores, Eva Jiménez‐Siebert, Elinor Morris, Steffi Klimke, Sarah Tschudin‐Sutter, Andreas R. Hierlemann, Timm Maier, Christoph Dehio, , Knut Drescher

The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.

bioRxiv · Feb 5, 2026 · PreprintMicrobiology

Antibiotics that Kill Gram-negative Bacteria by Restructuring the Outer Membrane Protein BamA

Seyed Majed Modaresi, Ryosuke Sugiyama, Nhan Dai Thien Tram, Roman Peter Jakob, Chin‐Soon Phan, Amir Ata Saei, Yohei Morishita, Tobias Mühlethaler, Joel Louis Lim, Danilo Ritz, Preston Shi Yang Long, Phillipe A Lehner, Zhi Chiaw Lim, Morris Degen, Ziwei Yao, , Brandon I. Morinaka

This study identifies xenorceptides, a new class of antibiotics that target BamA in Gram-negative bacteria, showing potent activity and limited resistance.

bioRxiv · Dec 16, 2024 · PreprintMicrobiology

High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica

Ricardo Diogo Righetto, Leonie Anton, Ricardo Adaixo, Roman Peter Jakob, Jasenko Zivanov, Mohamed-Ali Mahi, Philippe Ringler, Torsten F. Schwede, Timm Maier, Henning Stahlberg

The paper reports the high-resolution cryo-EM structure of urease from Yersinia enterocolitica, revealing the bimetal active site and enabling drug development insights.

Nature Communications · Oct 9, 2020Peer-reviewedMolecular Biology