Christoph Dehio

This study introduces HIDEN-SEQ, a transposon-insertion sequencing method for phages, to systematically map gene essentiality and uncover previously unknown viral anti-defense factors.

This study identifies how the intestinal microbiota drives the evolution of pathoadaptive traits in ESBL E. coli through adhesion and biofilm formation.

The paper develops genetically-encoded biosensors to monitor antibiotic concentrations inside bacterial cells and tissues in real-time, revealing antibiotic exposure dynamics and penetration in infection models.

This study uses CRISPRi to identify genetic factors affecting E. coli adaptation across diets, inflammation, and strains in a mouse model.

The paper identifies a subset of Brucella T4SS effector proteins that associate with outer membrane vesicles, suggesting an alternative secretion pathway.

This paper develops a 3D human urothelial model to study UTI dynamics and therapeutic responses in real-time.

This study uses CRISPRi to identify metabolic vulnerabilities of UPEC in urine, highlighting ALS II as a druggable target.

The paper identifies BrrG as an antiterminator that coordinates the expression of two divergent phage-derived modules in BaGTA, enhancing horizontal gene transfer in Bartonella.

This study identifies BspD as critical for maintaining Brucella envelope integrity under stress, showing its role in bacterial survival within host cells.

This study identifies YopJ homologs in Bartonella as T4SS effectors, showing they evolved from an ancestral T4SS effector through acquisition of a T3SS translocation signal.

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.

The paper determines the structure of cyclic beta-1,2-glucan synthase from Agrobacterium tumefaciens and clarifies its mechanism of action.

This study quantifies genomic, proteomic, and phenotypic variability in HeLa cells across laboratories and passages, revealing implications for research reproducibility.

The paper improves pathway reconstruction from RNAi screens by incorporating off-target effects into nested effects models, enhancing network accuracy.

The paper develops an integrative proteogenomics strategy to improve prokaryotic genome annotation by combining multiple resources and experimental data, identifying novel ORFs and correcting errors.