Targeting FSP1 triggers ferroptosis in lung cancer
Katherine Wu, Alec J. Vaughan, Jozef P. Bossowski, Yuan Hao, Aikaterini Ziogou, Seon Min Kim, Tae Ha Kim, Mari N. Nakamura, Ray Pillai, Mariana Camargo Silva Mancini, Sahith Rajalingam, Mingqi Han, Toshitaka Nakamura, Lidong Wang, Suckwoo Chung, , Thales Y. Papagiannakopoulos
Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.
Nature · Nov 5, 2025Peer-reviewedCancer Biology✦ In-depth digest