Author

A.-C. Gavin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Gehin· 3 shared M. L. Hennrich· 3 shared A. Chiapparino· 2 shared B. Mahata· 2 shared J. Pramanik· 2 shared K. Titeca· 2 shared L. Truebestein· 2 shared L. van Ek· 2 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

C. Gehin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A system-wide analysis of lipid transfer proteins delineates lipid mobility in human cells

K. Titeca, A. Chiapparino, D. Turei, J. Zukowska, L. van Ek, M. Moqadam, S. Triana, I. O. Nielsen, M. Moller Foged, C. Gehin, K. Maeda, T. Alexandrov, J. Saez-Rodriguez, N. Reuter, M. L. Hennrich, A.-C. Gavin

The paper identifies lipid cargoes for half of analyzed human LTPs, revealing selectivity for lipid head groups and acyl chains and new lipid-organelle relationships.

Nature · Jan 7, 2026Peer-reviewedBiochemistry

A Mechanistic Model for the Release of Ceramide from the CERT START Domain

M. Moqadam, P. Gartan, R. Talandashti, A. Chiapparino, K. Titeca, A.-C. Gavin, N. Reuter

The paper proposes a membrane-assisted mechanism for ceramide release from the CERT START domain using molecular simulations and validates it with experimental lipidomics data.

bioRxiv · Dec 16, 2023Biophysics

Development of genetically-encoded fluorescent KSR1-based probes to track ceramides during phagocytosis

V. Girik, L. Van Ek, I. Dentand Quadri, M. Azam, M. Cruz Cobo, M. Mandavit, I. Riezman, H. Riezman, A.-C. Gavin, P. Nunes-Hasler

This study develops genetically encoded fluorescent probes based on KSR1's ceramide-binding domain to track ceramide dynamics during phagocytosis and identifies distinct behaviors of different probe variants.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

S. Roy, S. Roy, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. A. Teichmann

The paper identifies pregnenolone targets and their binding conformations in Th2 cells using chemoproteomics and molecular dynamics simulations.

bioRxiv · May 23, 2023Immunology

Structure and regulation of the Myotonic dystrophy kinase-Related Cdc42-binding Kinase

L. Truebestein, E. Waltenberger, C. Gehin, A.-C. Gavin, T. A. Leonard

The paper presents the structure and membrane-binding properties of C. elegans MRCK1, revealing its homodimeric conformation and interactions with phosphoinositides and Cdc42.

bioRxiv · Mar 11, 2022Biochemistry

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

S. Sajko, I. Grishkovskaya, J. Kostan, M. Graewert, K. Setiawan, L. Truebestein, K. Niedermuller, C. Gehin, A. Sponga, M. Puchinger, A.-C. Gavin, T. Leonard, D. I. Svergun, T. K. Smith, B. C. Morriswood, K. Djinovic-Carugo

This study investigates MORN repeat proteins, revealing they are protein-protein interaction modules rather than lipid-binding modules, based on structural and functional analyses of TbMORN1 and homologs.

bioRxiv · Jun 23, 2020Biochemistry

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

S. Roy, J. Sipthorp, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. V. Ley, S. Teichmann

The paper maps pregnenolone interactomes in cancer and immune cells using chemical biology and chemoproteomics to identify proteins involved in its trafficking and non-genomic actions.

bioRxiv · Oct 16, 2019Biochemistry