Y. Yamaguchi

Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator

This study identifies Gpx4 and ferroptosis-suppressing pathways as key to cold resistance in hibernator cells, showing their potential to enhance cold tolerance in non-hibernators.

Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence

This study identifies an N-glycan shield on HSV-1 gB that mediates evasion from human antibodies in vivo and contributes to neurovirulence.

A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model

PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages

This study shows that PD-L1 blockade enhances CAR T cell activity by altering macrophage phenotypes through IFNγ signaling in the tumor microenvironment.

Frequency modulated timer regulates mammalian hibernation

The paper analyzes body temperature fluctuations in hibernating Syrian hamsters and identifies a frequency-modulated model governing torpor-interbout arousal cycles.

THz irradiation inhibits cell division by affecting actin dynamics

This study shows THz irradiation inhibits cell division by preventing the disappearance of the contractile ring and promoting F-actin polymerization in human cells.

Lipopolysaccharide preconditioning augments phagocytosis of malaria-parasitized red blood cells through induced bone marrow-derived macrophages in the liver, thereby increasing the murine survival after Plasmodium yoelii infection

This study shows that LPS preconditioning enhances phagocytic clearance of malaria parasites by liver macrophages, improving survival in mice infected with Plasmodium yoelii.

A new microcirculation culture method with a self-organized capillary network

This paper introduces a microcirculation culture method that creates a self-organized capillary network, enabling perfusion and observation of vascular remodeling and cell behavior.

Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

The paper identifies a conserved virulence factor in Streptococcus pneumoniae through evolutionary analysis and shows its role in immune evasion.

Sufficient therapeutic effect of cryopreserved frozen adipose-derived regenerative cells on burn wounds

This study shows that cryopreserved adipose-derived regenerative cells (ADRCs) are as effective as fresh ADRCs in promoting burn wound healing.