T. Boesen

Comparative electric and ultrastructural studies of cable bacteria reveal new components of conduction machinery

This study compares electric and ultrastructural features of cable bacteria, revealing conserved conduction mechanisms and novel metabolic structures.

Robust control of replication initiation in the absence of DnaA-ATP {leftrightharpoons} DnaA-ADP regulatory elements in Escherichia coli

The paper investigates the role of DnaA-ATP/ADP conversion in E. coli replication initiation, finding that intrinsic ATPase activity alone can maintain robust initiation, with regulatory elements enhancing stability during multifork replication.

Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus

This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.

Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase

This study reveals how PhnJ mediates ATP hydrolysis-induced structural changes in the C-P lyase complex, uncovering a novel ABC dimer configuration.

Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

The paper determines the structure and protein-protein interactions of ice nucleation proteins and shows they are essential for their activity.

On the reproductive mechanisms of protocells

This study investigates protocell reproduction by transforming bacterial cells into lipid vesicles and simulating Archaean conditions, finding that reproduction occurs through biophysical interactions and environmental factors.

On the nature of the earliest known life forms

This study reconstructs Archaean microfossils by transforming a bacterium into a lipid vesicle-like state, showing they likely represent liposome-like protocells with energy conservation but no morphology regulation.

Histidine-rich Ca2+-binding protein stimulates the transport cycle of SERCA through a conformation-dependent fuzzy complex.

This study shows HRC stimulates SERCA by binding in a conformation-dependent fuzzy complex, stabilizing the end of the SERCA transport cycle.

The Ice Nucleating Protein InaZ is Activated by Low Temperature

This study investigates how the ice-nucleating protein InaZ from Pseudomonas syringae folds and interacts with water at low temperatures, revealing structural changes that enhance ice nucleation.

Tracing the in Vivo Fate of Nanoparticles with a "Non-Self" Biological Identity

The paper investigates the in vivo fate of nanoparticles with a non-self protein corona in zebrafish embryos, showing rapid sequestration and inflammatory effects.

Namdinator - Automatic Molecular Dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps

Namdinator automates Molecular Dynamics Flexible Fitting to improve structural models in cryo-EM and crystallography maps, achieving model improvements in 87% of tested cases.