M. Lampe

Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis

The paper shows Cohesin replaces Condensin to rebuild genome architecture after mitosis, forming nested loop structures.

Reflection confocal microscopy for quantitative assessment of airway surface liquid dysregulation and pharmacological rescue in cystic fibrosis under near-physiological conditions

This paper introduces confocal reflection microscopy as a method to measure airway surface liquid height in cystic fibrosis models without perturbing the ASL, showing it is sensitive to detect ASL changes and therapeutic responses.

On the annotation of Paleo- and Mesoproterozoic microfossils as fungi

This study challenges the interpretation of Paleo- and Mesoproterozoic microfossils as fungi by showing bacteria can form protoplasts resembling fungal morphology under similar environmental conditions.

iMOUSE - Reforming the Strategy of Refinement and Reduction for indispensable laboratory animal-based studies in translational research

The paper introduces a digital monitoring system for animal-based studies to reduce human bias and stress, enabling reliable data collection and AI-driven motion analysis.

Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging

This paper introduces RhoBAST:SpyRho, a fluorescent probe for high-resolution RNA imaging, showing improved brightness, fluorogenicity, and performance in super-resolution techniques.

On the reproductive mechanisms of protocells

This study investigates protocell reproduction by transforming bacterial cells into lipid vesicles and simulating Archaean conditions, finding that reproduction occurs through biophysical interactions and environmental factors.

On the reproductive mechanism of Gram-negative protoplasts

This study demonstrates that Gram-negative protoplasts reproduce through a defined sequence influenced by environmental conditions and intracellular factors, showing efficient reproduction under favorable conditions.

Precision localization of cellular proteins with fluorescent Fab-based probes

This study introduces Fluo-N-Fabs, fluorescent reagents that reduce linkage error in super-resolution microscopy by over five-fold compared to conventional methods.

On the nature of the earliest known life forms

This study reconstructs Archaean microfossils by transforming a bacterium into a lipid vesicle-like state, showing they likely represent liposome-like protocells with energy conservation but no morphology regulation.

Photoactivation of silicon rhodamines via a light-induced protonation

This paper introduces a new photoactivatable fluorophore that enables live-cell super-resolution microscopy without caging groups or side-products.

Bleaching-independent, whole-cell, 3D and multi-color STED imaging with exchangeable fluorophores

The paper introduces a bleaching-independent STED microscopy method using exchangeable fluorophores, enabling long-term whole-cell 3D and multi-color imaging in live cells.

A quantitative map of human Condensins provides new insights into mitotic chromosome architecture

The paper quantifies Condensin I and II dynamics during mitosis, proposing a three-step loop model for chromosome compaction.