Author

L. J. Stewart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein design· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Baker· 2 shared K. J. Waldron· 2 shared K. Y. Djoko· 2 shared A. Ford· 1 shared A. G. McEwan· 1 shared A. K. Bera· 1 shared A. Roy· 1 shared A. Yang· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

D. Baker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo design of buttressed loops for sculpting protein functions

H. Jiang, K. M. Jude, K. Wu, J. Fallas, G. Ueda, T. Brunette, D. Hicks, H. Pyles, A. Yang, L. Carter, M. Lamb, X. Li, P. M. Levine, L. J. Stewart, K. C. Garcia, D. Baker

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

bioRxiv · Aug 22, 2023 · PreprintBiochemistry

Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.

Y. Hong, E. S. Mackenzie, S. J. Firth, J. F. Bolton, L. J. Stewart, K. J. Waldron, K. Y. Djoko

This study shows that Cu stress in GAS leads to mis-regulation of Zn and Mn homeostasis, affecting growth and lactate secretion, without altering cellular Cu levels.

bioRxiv · Sep 28, 2022 · PreprintMicrobiology

Large-scale design and refinement of stable proteins using sequence-only models

J. M. Singer, S. Novotney, D. Strickland, H. K. Haddox, N. Leiby, G. J. Rocklin, C. M. Chow, A. Roy, A. K. Bera, F. C. Motta, L. Cao, E.-M. Strauch, T. M. Chidyausiku, A. Ford, E. Ho, , E. Klavins

The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.

bioRxiv · Mar 12, 2021Biophysics

A role for glutathione in buffering excess intracellular copper in Streptococcus pyogenes

L. J. Stewart, C.-l. Y. Ong, M. M. Zhang, S. Brouwer, L. McIntyre, M. R. Davies, M. J. Walker, A. G. McEwan, K. J. Waldron, K. Y. Djoko

This study shows that glutathione buffers excess intracellular copper in Streptococcus pyogenes when the Cu export system is overwhelmed, allowing bacterial survival despite copper toxicity.

mBio · Dec 22, 2020Peer-reviewedMicrobiology