D. Perrais

Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor internalization

This study shows that membrane poly-unsaturated fatty acids (PUFAs) impair dopamine D2 receptor (D2R) endocytosis without affecting other GPCRs or clathrin-mediated endocytosis.

Emerging role of oncogenic β-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

This study shows that oncogenic β-catenin reduces exosome release in HCC, leading to immune escape by decreasing immune cell infiltration.

Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons

The paper develops a method to label and image masked epitopes of transmembrane proteins in live neurons using non-canonical amino acids and genetic code expansion.

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis

The paper shows that dynamin's efficient endocytosis requires multimeric interactions with SH3 domains through multiple motifs.

Semisynthetic pH-Sensitive Fluorophores For Imaging Exocytosis And Endocytosis

This paper develops semisynthetic pH-sensitive fluorophores that enable imaging of exocytosis and endocytosis, matching the performance of GFP-based pHluorin.