Author

S. P. Sinkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Organism:Arabidopsis· 5 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. V. Mancini· 5 shared T. H. Ant· 5 shared C. S. Herd· 3 shared J. Martinez· 3 shared S. M. Murdochy· 3 shared D. D. Gingell· 2 shared E. Mararo· 2 shared A. A. Hoffmann· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersMicrobiology

M. V. Mancini

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Rapid evolution of Wolbachia genomes in mosquito cell culture

J. Martinez, S. P. Sinkins

This study tracks short-term Wolbachia genome evolution in mosquito cell culture, identifying mutations linked to bacterial density changes and signs of selective evolution.

bioRxiv · Sep 20, 2023 · PreprintEvolutionary Biology

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.

C. J. McNamara, T. H. Ant, T. Harvey-Samuel, H. White-Cooper, J. Martinez, L. Alphey, S. P. Sinkins

This study shows that expressing cifA and cifB genes from Wolbachia strain wAlbB in Aedes aegypti testes induces CI-like sterility, which can be rescued by maternal cifA expression.

bioRxiv · Sep 1, 2023 · PreprintMicrobiology

Validation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model

M. V. Mancini, R. Tandavanitj, T. H. Ant, S. M. Murdochy, D. D. Gingell, C. Setthapramote, P. Natsrita, A. Kohl, S. P. Sinkins, A. H. Patel, G. De Lorenzo

This study validates a ZIKV vaccine candidate by testing its efficacy in a mosquito-mouse transmission model, showing protection against disease and reduced viral transmission.

bioRxiv · Aug 8, 2022 · PreprintMicrobiology

Wolbachia strain wAu differs in cellular perturbation and virus inhibition profiles from previously characterised Wolbachia strains

S. Rainey, V. Geoghegan, D. Lefteri, T. Ant, J. Martinez, C. McNamara, S. P. Sinkins

This study compares the cellular perturbation and antiviral profiles of Wolbachia strain wAu with other strains, finding unique features in its virus inhibition mechanisms.

bioRxiv · Sep 2, 2021 · PreprintMicrobiology

High temperature cycles result in maternal transmission and dengue infection differences between Wolbachia strains in Aedes aegypti

M. V. Mancini, T. H. Ant, C. S. Herd, D. D. Gingell, S. M. Murdochy, E. Mararo, S. P. Sinkins

This study examines how high temperature cycles affect Wolbachia density and dengue inhibition in two Aedes aegypti strains, showing differences in maternal transmission and virus blocking capacity between wMel and wAlbB.

bioRxiv · Nov 25, 2020Microbiology

Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus

M. V. Mancini, C. S. Herd, T. H. Ant, S. M. Murdochy, S. P. Sinkins

This study introduces Wolbachia strain wAu into Aedes albopictus, showing it blocks dengue and Zika transmission with minimal fitness cost.

PLOS Neglected Tropical Diseases · Mar 10, 2020Peer-reviewedMicrobiology

A Microsporidian blocks Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes

J. K. Herren, L. Mbaisi, E. Mararo, J. W. Oundo, E. Makhulu, H. Butungi, M. V. Mancini, V. A. Mobegi, J. Jabara, S. P. Sinkins

This study identifies a Microsporidia symbiont that blocks Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes without affecting mosquito survival or fecundity.

bioRxiv · Oct 9, 2019Microbiology

Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

W. A. Nazni, A. A. Hoffmann, A. Noor Afizah, Y. L. Cheong, M. V. Mancini, N. Golding, M. R. G. Kamarul, A. K. M. Arif, H. Thohir, H. S. Nur Syamimi, M. Z. Nur Zatil Aqmar, M. M. Nur Ruqqayah, A. Siti Nor Syazwani, A. Faiz, M. N. F. R. Irfan, , S. P. Sinkins

The paper describes the release of Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain in Malaysia to reduce dengue incidence, showing successful establishment and reduced human dengue cases in some areas.

bioRxiv · Sep 20, 2019Microbiology

TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV)

S. J. Rihn, M. A. Aziz, D. G. Stewart, J. Hughes, M. L. Turnbull, M. Varela, E. Sugrue, C. S. Herd, M. Stanifer, S. P. Sinkins, M. Palmarini, S. J. Wilson

This study identifies TRIM69 as an interferon-induced gene that potently inhibits VSIV, with specific antiviral activity and evolutionary signatures of positive selection.

bioRxiv · Jun 13, 2019Microbiology