Author

T. Heffernan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Carugo· 2 shared C. Zhu· 2 shared N. Feng· 2 shared A. Al-Shami· 1 shared A. Futreal· 1 shared A. Hefner· 1 shared A. J. C. Russell· 1 shared A. Sgambato· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

A. Carugo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolutionary fingerprints of EMT in pancreatic cancers

L. Perelli, L. Zhang, S. Mangiameli, A. J. C. Russell, F. Giannese, F. Peng, F. Carbone, C. Le, H. Khan, F. Citron, M. Soeung, T. Lam, S. Lundgren, C. Zhu, D. Catania, , G. Genovese

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

J. K. Allen, M. A. Gonzalez, J. Kaur, M. Smith, J. You, G. Yang, D. Zha, Z. Tian, A. Al-Shami, C. Shi, J. J. Molldrem, T. Heffernan

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

L. Yan, B. Tu, J. Yao, J. Gong, A. Carugo, C. Bristow, Q. Wang, C. Zhu, B. Dai, Y. Kang, L. Han, N. Feng, Y. Jin, J. Fleming, T. Heffernan, , H. Ying

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

bioRxiv · Jan 9, 2021Cancer Biology

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

M. Kumar, D. Molkentine, J. Molkentine, K. Bridges, T. Xie, L. Yang, A. Hefner, M. Gao, M. J. Frederick, S. Seth, M. Abdelhakiem, B. Beadle, F. M. Johnson, J. Wang, L. Shen, , H. D. Skinner

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

bioRxiv · Apr 10, 2020 · PreprintCancer Biology