Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis
T. L. Ollinger, B. Vu, D. Murante, J. Parker, L. Simonicova, L. A. Doorley, M. A. Stamnes, S. L. Kelly, P. D. Rogers, W. S. Moye-Rowley, D. J. Krysan
The paper identifies ROX1 as a negative regulator of ergosterol biosynthesis genes in C. glabrata and shows that its loss-of-function suppresses fluconazole hypersusceptibility in upc2AΔ mutants.
bioRxiv · Oct 7, 2021 · PreprintMicrobiology