W. S. Moye-Rowley

Calcineurin is required for Candida glabrata Pdr1 transcriptional activation

This paper shows calcineurin is required for fluconazole-induced Pdr1 activation and drug resistance in Candida glabrata, linking it to both azole and echinocandin resistance.

CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus

This paper identifies NcaA, a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus, showing its role in azole resistance.

Complex and critical roles for the AtrR transcription factor in control of cyp51A expression in Aspergillus fumigatus

This paper investigates the role of the AtrR transcription factor in regulating cyp51A expression in Aspergillus fumigatus and shows that its binding sites in duplicated promoter regions have distinct effects on gene expression and azole resistance.

Aspergillus fumigatus ffmA encodes a C2H2-containing transcriptional regulator that modulates azole resistance and is required for normal growth

This paper identifies ffmA as a C2H2 transcription factor in Aspergillus fumigatus that modulates azole resistance and normal growth through interactions with AtrR and regulation of AbcG1 expression.

Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis

The paper identifies ROX1 as a negative regulator of ergosterol biosynthesis genes in C. glabrata and shows that its loss-of-function suppresses fluconazole hypersusceptibility in upc2AΔ mutants.