M. Wellington

Temporal dynamics of Candida albicans morphogenesis and gene expression reveals distinctions between in vitro and in vivo filamentation.

This paper compares the temporal dynamics of morphogenesis and gene expression during C. albicans filamentation in vitro and in vivo, identifying key differences in metabolic gene expression and hyphae-to-yeast transition rates.

The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent

This study shows that the function of the C. albicans transcriptional repressor NRG1 varies by strain, affecting filamentation and virulence in different contexts.

Survival in macrophages induces enhanced virulence in Cryptococcus

The paper shows that Cryptococcus cells become more virulent after surviving in macrophages, with increased mannose and chitin exposure on their cell walls.

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism

This paper identifies a rare, dominant SNP in the Rob1 transcription factor of C. albicans strain SC5314 that enhances biofilm formation and filamentation, contributing to its distinct phenotypic traits.

Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

The paper uses intravital imaging to screen transcription factor mutants in C. albicans, identifying key regulators of filamentation during mammalian infection and revealing new insights into Efg1's function.

Split selectable marker mediated gene stacking in plants

This paper introduces a split selectable marker system using inteins for Agrobacterium-mediated co-transformation in plants, enabling the simultaneous insertion of multiple genes into Arabidopsis and poplar.

Candida albicans filamentation does not require the cAMP-PKA pathway in vivo

This study shows that the cAMP-PKA pathway is not required for C. albicans filamentation in vivo, despite being essential in vitro.

FKS1 is required for Cryptococcus neoformans fitness in vivo: application of copper-regulated gene expression to mouse models of cryptococcosis

This paper uses copper-regulated gene expression to study FKS1 in C. neoformans, showing reduced in vivo fungal burden with lower FKS1 expression.

In vivo complex haploinsufficiency-based genetic analysis identifies a transcription factor circuit regulating Candida albicans oropharyngeal infection and epithelial cell endocytosis

The paper identifies a transcription factor circuit regulating C. albicans oropharyngeal infection and epithelial cell endocytosis through genetic interaction analysis in a mouse model.

Intravital imaging of Candida albicans identifies differential in vitro and in vivo filamentation phenotypes for transcription factor deletion mutants

This paper uses intravital imaging to compare in vitro and in vivo filamentation phenotypes of C. albicans transcription factor mutants, finding distinct regulatory patterns in vivo.

Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility

This study identifies CO2 tolerance as a virulence trait in Cryptococcus neoformans, linking it to disease severity and antifungal drug susceptibility.