Author

T. Mikkelsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. deCarvalho· 2 shared C. Mueller· 2 shared H. Kim· 2 shared H. Noushmehr· 2 shared L. M. Poisson· 2 shared R. Verhaak· 2 shared A. Bihouee· 1 shared A. C. deCarvalho· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. deCarvalho

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Author profile →

5 papers

Recent·Most cited

Impact of genomic background and developmental state on signaling pathways and response to therapy in Glioblastoma patient-derived cells

A. D. Berezovsky, O. Nuga, I. Datta, K. Bergman, T. Sabedot, K. Gurdziel, S. Irtenkauf, L. Hasselbach, Y. Meng, C. Mueller, E. Petricoin, S. Brown, N. Purandare, S. Aras, T. Mikkelsen, , A. deCarvalho

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

bioRxiv · Mar 14, 2024 · PreprintCancer Biology

Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

W. N. Al-Holou, H. Wang, V. Ravikumar, M. Oneka, R. Verhaak, H. Kim, D. Pratt, S. Camelo-Piragua, C. Speers, D. Wahl, S. Shankar, T. Hollon, O. Sagher, J. Heth, K. Muraszko, , A. Rehemtulla

This paper identifies THY1-positive, mesenchymal/stem-like cells as drivers of glioblastoma recurrence and shows that targeting TGFβ signaling can restore sensitivity to therapy.

bioRxiv · Sep 10, 2021Cancer Biology

Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectoderm

D. Meistermann, S. Loubersac, A. Reigner, J. Firmin, V. Francois - - Campion, S. Kilens, Y. Lelievre, J. Lammers, M. Feyeux, P. Hulin, S. Nedellec, B. Bretin, S. Covin, G. Castel, A. Bihouee, , L. David

This study uses transcriptomic pseudotime modeling and spatial data to reveal lineage specification dynamics in human preimplantation embryos, showing TE and ICM differentiation occurs at the blastocyst stage.

bioRxiv · Apr 10, 2019Cell Biology

Detection of glioma and prognostic subtypes by non-invasive circulating cell-free DNA methylation markers

H. Noushmehr, T. S. Sabedot, T. M. Malta, K. Nelson, J. Snyder, M. Wells, A. deCarvalho, A. Makherjee, D. Chitale, M. Mosella, K. Asmaro, A. M. Robin, M. L. Rosenblum, T. Mikkelsen, J. Rock, , A. V. Castro

This study identifies non-invasive circulating DNA methylation markers that can detect glioma and predict its prognosis from serum samples.

bioRxiv · Apr 8, 2019 · PreprintCancer Biology

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

A. C. deCarvalho, H. Kim, L. M. Poisson, M. E. Winn, C. Mueller, D. Cherba, J. Koeman, S. Seth, A. Protopopov, M. Felicella, S. Zheng, A. Multani, Y. Zhang, J. Zhang, D.-H. Nam, , R. Verhaak

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.

bioRxiv · Jun 27, 2017Cancer Biology