D. Wahl

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

This study shows that Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function in aged and tauopathy mouse models.

Mobile retroelements induced by hypomethylating agents are restricted to transpose in myeloid malignancies

The paper investigates whether hypomethylating agents induce retroelement activity and somatic retrotranspositions in myeloid malignancies but finds no de novo retrotransposition events.

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

This paper identifies THY1-positive, mesenchymal/stem-like cells as drivers of glioblastoma recurrence and shows that targeting TGFβ signaling can restore sensitivity to therapy.