T. Nagashima

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

Exploration of novel αβ-protein folds through de novo design

This study predicts and designs novel β-protein folds using topology rules, demonstrating their feasibility and suggesting a vast untapped space of possible folds.

Design of complicated all-α protein structures

This study designs complex all-α protein structures using helix-loop-helix motifs and canonical α-helices, achieving atomic accuracy and thermal stability in solution.

Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice

This study develops a microdevice for compartmentalized coculturing of motor neurons and skeletal muscle tissues to form functional neuromuscular junctions and test drug responses.