N. Koga

Exploration of novel αβ-protein folds through de novo design

This study predicts and designs novel β-protein folds using topology rules, demonstrating their feasibility and suggesting a vast untapped space of possible folds.

Design of complicated all-α protein structures

This study designs complex all-α protein structures using helix-loop-helix motifs and canonical α-helices, achieving atomic accuracy and thermal stability in solution.

De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function

The paper designs allosteric control into V1-ATPase by restoring lost ATP binding function in pseudo-enzyme subunits, showing tunable acceleration through modulated binding affinity.

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.