T. Ogura

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

Protective effects of Mkl1/2 against lipodystrophy and muscle atrophy via PI3K/AKT-independent FoxO repression

This study shows Mkl1/2 repress FoxO transcription independently of PI3K/AKT, protecting against lipodystrophy and muscle atrophy by maintaining adipose and muscle tissue.

Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach

This study identifies an inter-organ mechanism of idiopathic pulmonary fibrosis (IPF) using a generative computational approach, revealing a liver-lung crosstalk involving kininogen 1 and bradykinin receptor B1.

Isotope-based visualization of element distribution in phloem provides functional evidence for the operation of SOS1 Na+/H+ exchangers in mature zones of Arabidopsis root

The paper uses radioisotope imaging and ion flux measurements to show that Na+ efflux via SOS1 occurs in mature root zones, not just the root apex, in Arabidopsis.

Distinct roles and actions of PDI family enzymes in catalysis of nascent-chain disulfide formation

This study compares the efficiency of PDI and ERp46 in catalyzing disulfide bond formation in nascent chains during translation, showing ERp46 is more effective early on.

EXOCYST70A3 controls root system depth in Arabidopsis via the dynamic modulation of auxin transport

This study identifies EXOCYST70A3 as a regulator of root system depth in Arabidopsis by modulating PIN4 protein distribution and auxin transport, affecting drought resistance.

Pirfenidone attenuates lung fibrotic fibroblast-mediated fibrotic responses to transforming growth factor-β1

This study shows pirfenidone reduces fibrotic responses in lung fibroblasts by inhibiting CTHRC1, suggesting it as a potential therapeutic target for lung fibrosis.