H. Takeda

Maternal high-fat diet affects the contents of eggs and causes abnormal development in the medaka fish

This study shows that maternal high-fat diet in medaka fish leads to egg content changes and increased embryonic deformities in offspring.

A procedure for solid phase extractions using metal oxide coated silica column in lipidomics

The paper introduces a solid-phase extraction method using metal oxide-coated silica columns to fractionate lipids into neutral, phospholipids, and other lipid classes for lipidomics.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

This study uses single-cell genomics to analyze Endozoicomonas bacteria in Acropora tenuis corals, revealing host-adaptive genes that may enhance coral stress tolerance.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Genome-Scale CRISPR Screening reveals novel factors regulating Wnt-dependent regeneration of mouse gastric organoids

The paper uses CRISPR screening to identify novel factors regulating Wnt-dependent regeneration of mouse gastric organoids, finding that Alk, Bclaf3, and Prkra suppress Wnt-driven self-renewal.

PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide

The paper identifies PLZF as a CRBN substrate degraded by thalidomide and 5-hydroxythalidomide, linking it to teratogenesis.

Evolutionary transition in accessible chromatin landscapes during vertebrate embryogenesis

The paper shows that more evolutionarily derived gene regulatory regions are activated later in embryogenesis across three vertebrate species.

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

The paper studies zebrafish PIH proteins to determine their roles in axonemal dynein assembly and cilia/flagella motility, finding that each PIH protein is associated with specific dynein subtypes.

ZMYND10 functions in a chaperone relay during axonemal dynein assembly

This study identifies ZMYND10 as a co-chaperone for FKBP8-HSP90 in axonemal dynein assembly, showing its role in ciliary motility and implications for PCD treatment.