T. T. Le

Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential

This study identifies cell morphology as the best predictor of metastatic potential in TNBC cell lines using in vivo and in vitro assays.

ACE2-independent SARS-CoV-2 infection and mouse adaption emerge after passage in cells expressing human and mouse ACE2

The paper describes the generation of mouse-adapted SARS-CoV-2 variants through serial passaging in co-cultures of human and mouse ACE2-expressing cells, revealing ACE2-independent infection capabilities.

Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy

This study reports the genomes of phages and A. baumannii isolates from a phage therapy case, showing rapid resistance development and identifying capsule locus mutations linked to phage insensitivity.

Sensory nerves enhance triple-negative breast cancer migration and metastasis via the axon guidance molecule PlexinB3

This study shows sensory nerves promote TNBC migration and metastasis through PlexinB3-mediated adhesion and gene expression changes.

Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

This study shows that microplastic consumption in mice causes mild colon inflammation and prolongs viral arthritis by increasing Th1, NK cell, and neutrophil signatures.

Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer

This study shows that altering potassium channel expression changes resting membrane potential in TNBC cells, increasing invasion and metastasis through cadherin-11 and MAPK pathway changes, and suggests repurposing potassium channel blockers as a therapeutic strategy.

RNA-sequencing indicates immune cell signaling and inflammatory gene expression in cardiac fibroblasts increases with developmental age

This study uses RNA-seq to analyze cardiac fibroblasts from fetal, neonatal, and adult rats, finding increased immune signaling and inflammatory gene expression with age.

ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

This paper develops an ACE2-lentivirus system to enable SARS-CoV-2 infection in mice, showing it can model viral replication, inflammation, and vaccine testing.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

From the inside out: An epibiotic Bdellovibrio predator with an expanded genomic complement

The paper describes Bdellovibrio qaytius, an epibiotic predator with a complex genome similar to periplasmic predators, suggesting epibiotic predation may be ancestral in the genus.