Author

T. Tammela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Singhal· 2 shared L. E. Dow· 2 shared S. W. Lowe· 2 shared A. D. Warren· 1 shared A. Levchenko· 1 shared C. Haglund· 1 shared C. M. Rudin· 1 shared C.-H. Pan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Singhal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

Z. Li, X. Zhuang, C.-H. Pan, Y. Yan, R. Thummalapalli, J. Hallin, S. Torborg, A. Singhal, J. C. Chang, E. Manchado, L. E. Dow, R. Yaeger, J. G. Christensen, S. W. Lowe, C. M. Rudin, , T. Tammela

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

bioRxiv · Sep 29, 2023Cancer Biology

Noninvasive lung cancer detection via pulmonary protease profiling

J. Kirkpatrick, A. D. Warren, T. Tammela, P. M. K. Westcott, J. C. Voog, T. Jacks, S. N. Bhatia

This study uses activity-based nanosensors to detect early-stage lung cancer in mice with high sensitivity and specificity through urinary readouts of protease activity.

bioRxiv · Dec 13, 2018 · PreprintCancer Biology