R. Yaeger

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.